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Investigation of Moringa Leaf Compounds as Colon Anticancer Agents Using Bioinformatics and Molecular Docking Methods
Corresponding Author(s) : Rifki Febriansah
Proceedings University of Muhammadiyah Yogyakarta Undergraduate Conference,
Vol. 2 No. 2 (2022): Strengthening Youth Potential for Sustainable Innovation
Abstract
Introduction - Colon cancer is a disease that has a high mortality rate. Cancer treatments such as chemotherapy can cause severe side effects. So, it is necessary to do research on herbal plants to minimize these side effects. The bioactive compounds in Moringa leaves (Moringa oleifera L.) are known to have antioxidant and anticancer activity, so they have the potential to be used as cancer treatment. Purpose – . This study aims to determine the potential of Moringa leaves as an anticancer agent in silico.
Methodology/Approach – The in silico test used is STITCH-STRING bioinformatics and molecular docking. STITCH-STRING bioinformatics was used to determine the target protein of the test compound, and molecular docking was used to determine the binding affinity between the test compound and cancer protein. Findings – In the STITCH-STRING bioinformatics test, the potential targets for kaempferol and quercetin were TP53-ESR1 and STAT3-EGFR, respectively.test Molecular docking on cancer protein showed that quercetin compound in EGFR protein had the best binding with a docking score of -9.2 kcal/mol. This shows good results because the docking score obtained is lower than the comparison drug (Fluorouracil) which has a docking score of -4.2 kcal/mol. These results indicate that compounds in Moringa leaves (Moringa oleifera L.) have the potential to be used as anticancer agents. Originality/ Value/ Implication – Moringa leaf research using bioinformatics and molecular docking methods is still rarely done, so this research can be used as further knowledge related to the search for moringa leaf compounds that have the potential for anticancer using bioinformatics and molecular docking methods
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- Afiyah, R. K. (2018). Dukungan Keluarga Mempengaruhi Kemampuan Adaptasi (Penerapan Model Adaptasi Roy) Pada Pasien Kanker Di Yayasan Kanker Indonesia Cabang Jawa Timur. Journal of Health Sciences, 10(1), 96–105. https://doi.org/10.33086/jhs.v10i1.15
- Hardiyanthi, F.: Pemanfaatan Aktivitas Antioksidan Ekstrak Daun Kelor (Moringa oleifera) dalam Sediaan Hand and Body Cream. Skripsi, Fakultas Sains dan Teknologi UIN Syarif Hidayatullah, Jakarta, 2015.
- Hardiyanthi, F.: Pemanfaatan Aktivitas Antioksidan Ekstrak Daun Kelor (Moringa oleifera) dalam Sediaan Hand and Body Cream. Skripsi, Fakultas Sains dan Teknologi UIN Syarif Hidayatullah, Jakarta, 2015
- Hazani, K.F. (2014). Pengaruh pemberian ekstrak etanol daun kelor (Moringa oleifera L.) terhadap kadar Malondialdehide (MDA) dan kualitas spermatozoa epididimis mencit (Mus musculus L) yang dipapar timbal (Pb) asetat.Undergraduate thesis, Universitas Islam Negeri Maulana Malik Ibrahim Malang.
- Hermawan, A. et al. 2021. ‘Bioinformatics and in vitro studies reveal the importance of p53, PPARG and notch signaling pathway in inhibition of breast cancer stem cells by hesperetin’, Advanced Pharmaceutical Bulletin, 11(2), pp. 351–360. doi: 10.34172/apb.2021.033.
- Krisnadi AD. 2010. Kelor Super Nutrisi. Blora: Pusat Informasi dan Pengembangan Tanaman Kelor Indonesia
- Mangan, Y. (2009). Solusi sehat mencegah & mengatasi kanker. Jakarta: Agromedia Pustaka.
- Purwanto, D.S., Susanti, H., & Sugihartini, N. (2021). Docking Molekuler Potensi Anti Inflamasi Quersetin Daun Kelor (Moringa oleifera L.) dengan Autodock-Vina. Jurnal Ilmiah Manusia dan Kesehatan. Vol 4, 309-313
- Putri, P. V. P., Susanti, N. M. P., & Laksmiani, N. P. L. (2019). Senyawa Kuersetin sebagai Agen Antikanker Kolorektal secara In Silico. Jurnal Kimia, 13(2): 166–171.
- Rastini, M.B.O., Giantari, N.K.M., Adnyani, K.D., and Laksmiani, N.P.L. (2019). Molecular docking aktivitas antikanker dari kuersetin terhadap kanker payudara secara in silico. Journal of chemistry. 13(2): 180-184.
- Roloff A., Weisgerber, H., Lang, U. et al. (2009). Moringa oleifera Lam, Enzyklopädie der Holzgewächse, vol. 40, pp. 1 – 8.
- Vergara-Jimenez, M., Almatrafi, M. M., dan Fernandez, M. L. (2017). Bioactive Components in Moringa Oleifera Leaves Protect against Chronic Disease. Antioxidants. 6 (91):1
References
Afiyah, R. K. (2018). Dukungan Keluarga Mempengaruhi Kemampuan Adaptasi (Penerapan Model Adaptasi Roy) Pada Pasien Kanker Di Yayasan Kanker Indonesia Cabang Jawa Timur. Journal of Health Sciences, 10(1), 96–105. https://doi.org/10.33086/jhs.v10i1.15
Hardiyanthi, F.: Pemanfaatan Aktivitas Antioksidan Ekstrak Daun Kelor (Moringa oleifera) dalam Sediaan Hand and Body Cream. Skripsi, Fakultas Sains dan Teknologi UIN Syarif Hidayatullah, Jakarta, 2015.
Hardiyanthi, F.: Pemanfaatan Aktivitas Antioksidan Ekstrak Daun Kelor (Moringa oleifera) dalam Sediaan Hand and Body Cream. Skripsi, Fakultas Sains dan Teknologi UIN Syarif Hidayatullah, Jakarta, 2015
Hazani, K.F. (2014). Pengaruh pemberian ekstrak etanol daun kelor (Moringa oleifera L.) terhadap kadar Malondialdehide (MDA) dan kualitas spermatozoa epididimis mencit (Mus musculus L) yang dipapar timbal (Pb) asetat.Undergraduate thesis, Universitas Islam Negeri Maulana Malik Ibrahim Malang.
Hermawan, A. et al. 2021. ‘Bioinformatics and in vitro studies reveal the importance of p53, PPARG and notch signaling pathway in inhibition of breast cancer stem cells by hesperetin’, Advanced Pharmaceutical Bulletin, 11(2), pp. 351–360. doi: 10.34172/apb.2021.033.
Krisnadi AD. 2010. Kelor Super Nutrisi. Blora: Pusat Informasi dan Pengembangan Tanaman Kelor Indonesia
Mangan, Y. (2009). Solusi sehat mencegah & mengatasi kanker. Jakarta: Agromedia Pustaka.
Purwanto, D.S., Susanti, H., & Sugihartini, N. (2021). Docking Molekuler Potensi Anti Inflamasi Quersetin Daun Kelor (Moringa oleifera L.) dengan Autodock-Vina. Jurnal Ilmiah Manusia dan Kesehatan. Vol 4, 309-313
Putri, P. V. P., Susanti, N. M. P., & Laksmiani, N. P. L. (2019). Senyawa Kuersetin sebagai Agen Antikanker Kolorektal secara In Silico. Jurnal Kimia, 13(2): 166–171.
Rastini, M.B.O., Giantari, N.K.M., Adnyani, K.D., and Laksmiani, N.P.L. (2019). Molecular docking aktivitas antikanker dari kuersetin terhadap kanker payudara secara in silico. Journal of chemistry. 13(2): 180-184.
Roloff A., Weisgerber, H., Lang, U. et al. (2009). Moringa oleifera Lam, Enzyklopädie der Holzgewächse, vol. 40, pp. 1 – 8.
Vergara-Jimenez, M., Almatrafi, M. M., dan Fernandez, M. L. (2017). Bioactive Components in Moringa Oleifera Leaves Protect against Chronic Disease. Antioxidants. 6 (91):1