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The Use of Crustacea Shell Extract as a Biocoagulant in Open Fracture
Corresponding Author(s) : Alifia Ichsan Nabila
Proceedings Universitas Muhammadiyah Yogyakarta Undergraduate Conference,
Vol. 1 No. 2 (2021): Engaging Youth in Community Development to Strengthen Nation's Welfare
Abstract
In recent years, shrimp is one of Indonesia's biggest fisheries export. It is causing a dramatic increase in shrimp shell waste production but yet a minimum way of utilization. Its most valuable material, chitosan, is called the magic of nature for its wide application, especially as a biocoagulant. Chitosan is a natural polysaccharide with a positive ion that can initiate the aggregation of red blood cells around the wound and form a thrombus. Chitosan is isolated from chitin by demineralization and deproteinization process that will determine the degree of deacetylation. Here, we investigate further whether it can effectively work as a biocogulant to control hemostasis in an emergency case like an open fracture. An open fracture is the most serious case of orthopedic injuries with early hemorrhage as one of the main causes of death. We found that gauze with chitosan-based can lessen bleeding without additional compression. In vitro study showed the effect of shortening clotting time that is essential to stop bleeding. The purpose of this literature review is to gain an understanding of the latest research relevant to the use of chitosan extract as a biocoagulant, including national and international articles and journals from 2011-2021 with a narrative method. The results show that chitosan can initiate red blood cell aggregation and shorten the clotting time rate.
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- C. Bartow-Mckenney et al. (2018). The microbiota of traumatic, open fracture wounds is associated with mechanism of injury HHS Public Access,” Wound Repair Regen, vol. 26, no. 2, pp. 127–135, 2018, doi: 10.1111/wrr.12642.
- Dompeipen, E.J., Marni, K., Dewa, R.P., (2016). Isolasi Kitin Dan Kitosan Dari Limbah Kulit Udang. Maj. BIAM 12 (01), 32–38.
- Dowling, M.B., Kumar, R., Keibler, M.A., Hess, J.R., Bochicchio, G. V., Raghavan, S.R., (2011). A self-assembling hydrophobically modified chitosan capable of reversible hemostatic action. Biomaterials 32, 3351–3357. https://doi.org/10.1016/j.biomaterials.2010.12.033
- Durachim, A., Astuti, D., (2018). Bahan Ajar Teknologi Laboratorium Medik (TLM) : Hemostasis. Kementrian Kesehatan RI.
- Fauzziah, Prilly Alya., Indriawati, Ratna. (2020). Potential of Crustacea Shell Extract in Open Fracture Healing. Proceedings The 1st UMYGrace 2020 (Universitas Muhammadiyah Yogyakarta Undergraduate Conference). ISBN: 978-623-7054-44-3.
- Hattori, H., Ishihara, M., (2015). Changes in blood aggregation with differences in molecular weight and degree of deacetylation of chitosan. Biomed. Mater. 10, 015014. https://doi.org/10.1088/1748-6041/10/1/015014
- Hu, Z., Zhang, D.-Y., Lu, S.-T., Li, P.-W., Li, S.-D., (2018). Chitosan-Based Composite Materials for Prospective Hemostatic Applications. Mar. Drugs 16, 273. https://doi.org/10.3390/md16080273
- Huang, Y., Feng, L., Zhang, Y., He, L., Wang, C., Xu, J., Wu, J., Kirk, T. B., Guo, R., & Xue, W. (2017). Hemostasis mechanism and applications of N-alkylated chitosan sponge. Polymers for Advanced Technologies, 28(9), 1107–1114. https://doi.org/10.1002/pat.4003
- Kementrian Kelautan dan Perikanan, (2019). Laporan Tahunan KKP 2019. Kementrian Kelautan dan Perikanan RI, Jakarta.
- Kementrian Kelautan dan Perikanan, (2016). Laporan Tahunan KKP 2016. Kementrian Kelautan dan Perikanan RI, Jakarta.
- Kunio, N.R., Riha, G.M., Watson, K.M., Differding, J.A., Schreiber, M.A., Watters, J.A., (2013). Chitosan based advanced hemostatic dressing is associated with decreased blood loss in a swine uncontrolled hemorrhage model. Am. J. Surg. 205, 505–510.
- Oryan A, Alidadi S, Moshiri A, 2013. Current concerns regarding healing of bone defects. Hard Tissue 2, 13.
- Sari, E., Herawati, Anshori, U., Nurmayulis, (2019). Biocoagulant of blood based on chitosan nanoparticle from crustacea. J. Phys. Conf. Ser. 1246. https://doi.org/10.1088/1742-6596/1246/1/012055
- Stepniewski, M., Martynkiewicz, J., & Gosk A-C, J. (2017). Address for correspondence Funding sources none declared Chitosan and its composites: Properties for use in bone substitution. Polymers in Medicine, 47(1), 49–53. https://doi.org/10.17219/pim/76517
- Umar, I., RW Sujud, (2020). Hemostasis dan Disseminated Intravascular Coagulation (DIC). J. Anasthesia Pain 1(2), 19–32
- Wiarto G, 2017. Nyeri Tulang dan Sendi. Yogyak. Gosyen Publ.
References
C. Bartow-Mckenney et al. (2018). The microbiota of traumatic, open fracture wounds is associated with mechanism of injury HHS Public Access,” Wound Repair Regen, vol. 26, no. 2, pp. 127–135, 2018, doi: 10.1111/wrr.12642.
Dompeipen, E.J., Marni, K., Dewa, R.P., (2016). Isolasi Kitin Dan Kitosan Dari Limbah Kulit Udang. Maj. BIAM 12 (01), 32–38.
Dowling, M.B., Kumar, R., Keibler, M.A., Hess, J.R., Bochicchio, G. V., Raghavan, S.R., (2011). A self-assembling hydrophobically modified chitosan capable of reversible hemostatic action. Biomaterials 32, 3351–3357. https://doi.org/10.1016/j.biomaterials.2010.12.033
Durachim, A., Astuti, D., (2018). Bahan Ajar Teknologi Laboratorium Medik (TLM) : Hemostasis. Kementrian Kesehatan RI.
Fauzziah, Prilly Alya., Indriawati, Ratna. (2020). Potential of Crustacea Shell Extract in Open Fracture Healing. Proceedings The 1st UMYGrace 2020 (Universitas Muhammadiyah Yogyakarta Undergraduate Conference). ISBN: 978-623-7054-44-3.
Hattori, H., Ishihara, M., (2015). Changes in blood aggregation with differences in molecular weight and degree of deacetylation of chitosan. Biomed. Mater. 10, 015014. https://doi.org/10.1088/1748-6041/10/1/015014
Hu, Z., Zhang, D.-Y., Lu, S.-T., Li, P.-W., Li, S.-D., (2018). Chitosan-Based Composite Materials for Prospective Hemostatic Applications. Mar. Drugs 16, 273. https://doi.org/10.3390/md16080273
Huang, Y., Feng, L., Zhang, Y., He, L., Wang, C., Xu, J., Wu, J., Kirk, T. B., Guo, R., & Xue, W. (2017). Hemostasis mechanism and applications of N-alkylated chitosan sponge. Polymers for Advanced Technologies, 28(9), 1107–1114. https://doi.org/10.1002/pat.4003
Kementrian Kelautan dan Perikanan, (2019). Laporan Tahunan KKP 2019. Kementrian Kelautan dan Perikanan RI, Jakarta.
Kementrian Kelautan dan Perikanan, (2016). Laporan Tahunan KKP 2016. Kementrian Kelautan dan Perikanan RI, Jakarta.
Kunio, N.R., Riha, G.M., Watson, K.M., Differding, J.A., Schreiber, M.A., Watters, J.A., (2013). Chitosan based advanced hemostatic dressing is associated with decreased blood loss in a swine uncontrolled hemorrhage model. Am. J. Surg. 205, 505–510.
Oryan A, Alidadi S, Moshiri A, 2013. Current concerns regarding healing of bone defects. Hard Tissue 2, 13.
Sari, E., Herawati, Anshori, U., Nurmayulis, (2019). Biocoagulant of blood based on chitosan nanoparticle from crustacea. J. Phys. Conf. Ser. 1246. https://doi.org/10.1088/1742-6596/1246/1/012055
Stepniewski, M., Martynkiewicz, J., & Gosk A-C, J. (2017). Address for correspondence Funding sources none declared Chitosan and its composites: Properties for use in bone substitution. Polymers in Medicine, 47(1), 49–53. https://doi.org/10.17219/pim/76517
Umar, I., RW Sujud, (2020). Hemostasis dan Disseminated Intravascular Coagulation (DIC). J. Anasthesia Pain 1(2), 19–32
Wiarto G, 2017. Nyeri Tulang dan Sendi. Yogyak. Gosyen Publ.