Correlation of Antihypertensive Drugs Ca-Antagonist Amlodipine with Xerostomia
DOI:
https://doi.org/10.18196/imunity.v1i1.22Keywords:
Xerostomia, Antihypertensives, Hyposalivation, Salivary Flow, HypertensionAbstract
Xerostomia is defined as a subjective complaint of dry mouth. Interestingly, patients complaining of dry mouth often have no objective signs of decreased salivation and their symptoms vary. May be secondary to qualitative and/or quantitative factors. changes in the composition of saliva. Normal stimulated salivary flow averages 1.5-2.0 ml/min while unstimulated salivary flow is about 0, 3-0.4 ml/min. This review aimed to determine the correlation between the Ca antagonist of the antihypertensive drug (Amlodipine) and xerostomia through a literature review conducted by researchers which was used as a reference for making this literature review. Data were obtained by data collection methods related to the study being studied and analyzed descriptively. Several studies show that there are differences in prevalence between genders and xerostomia appears to increase with age. A possible explanation is that older people are at risk due to some xerogenic medications for their chronic conditions and this may cause an overall decrease in the rate of unstimulated saliva flow. Xerostomia remains a common unresolved complaint especially among the geriatric population, despite efforts for medical or dental consultation. It was concluded that Ca-Antagonist antihypertensive drugs (amlodipine) were associated with xerostomia.
References
Tanasiewicz M, Hildebrandt T, Obersztyn I. Xerostomia of various etiologies: A review of the literature. Vol. 25, Advances in Clinical and Experimental Medicine Wroclaw University of Medicine; 2016. p. 199–206.
Villa A, Connell C, Abati S. Diagnosis and management of xerostomia and hyposalivation. Ther Clin Risk Manag. 2014;45. DOI: 10.2147/TCRM.S76282
Fox PC, Busch KA, Baum BJ. Subjective reports of xerostomia and objective measures of salivary gland performance. The Journal of the American Dental Association. 1987;115(4):581–4. DOI: 10.1016/S0002-8177(87)54012-0
DePalma SM, Himmelfarb CD, MacLaughlin EJ, Taler SJ. Hypertension guideline update. JAAPA. 2018;31(6):16–22. DOI: 10.1097/01.JAA.0000533656.93911.38
Millsop JW, Wang EA, Fazel N. Etiology, evaluation, and management of xerostomia. Clin Dermatol. Elsevier Inc.; 2017;35(5):468–76. DOI: 10.1016/j.clindermatol.2017.06.010
Al-Maweri SA, Altayyar MO, Alqahtani KW, Bamasud MS, Alghamdi OY, Ashraf S, et al. Xerostomia, salivary flow, and oral health status among saudi diabetic patients: A comparative cross-sectional study. Clin Cosmet Investig Dent. Dove Medical Press Ltd; 2021;13:451–8. DOI: 10.2147/CCIDE.S337581
Aliko A, Wolff A, Dawes C, Aframian D, Proctor G, Ekström J, et al. World Workshop on Oral Medicine VI: clinical implications of medication-induced salivary gland dysfunction. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015;120(2):185–206. DOI: 10.1016/j.oooo.2014.10.027
Tanasiewicz M, HILDEBRANDT T, Obersztyn I. Xerostomia of Various Etiologies: A Review of the Literature. Advances in Clinical and Experimental Medicine. 2016;25(1):199–206. DOI: 10.17219/acem/29375
Martínez-Acitores LR, de Azcárate FHR, Casañas E, Serrano J, Hernández G, López-Pintor RM. Xerostomia and aalivary flow in patients taking antihypertensive drugs. Vol. 17, International Journal of Environmental Research and Public Health MDPI; 2020.
Sakr M (Ed. ). Diagnostic Techniques and Therapeutic Strategies for Parotid Gland Disorders. IGI Global; 2020.
Supit KY, Wowor VNS, Mintjelungan CN. Hubungan Penggunaan Obat-obatan Antihipertensi dengan Terjadinya Xerostomia. e-GiGi. 2022;11(1):9. DOI: 10.35790/eg.v11i1.43089
Wotulo FG, Wowor PM, Supit ASR. Perbedaan Laju Aliran Saliva pada Pengguna Obat Antihipertensi Amlodipin dan Kaptopril di Kelurahan Tumobui Kota Kotamobagu. e-GIGI. 2018;6(1). DOI: 10.35790/eg.6.1.2018.19728
Usman NA, Hernawan I, Airlangga U. Tata Laksana Xerostomia Oleh Karena Efek Penggunaan Amlodipine: Laporan Kasus Management of Xerostomia Caused By Amlodipine: Case Report. Vol. 6, Insisiva Dental Journal Bulan.
Millsop JW, Wang EA, Fazel N. Etiology, evaluation, and management of xerostomia. Clin Dermatol. 2017;35(5):468–76. DOI: 10.1016/j.clindermatol.2017.06.010
